The Sindecuse Museum was created in 1991 with a gift from Gordon H. Sindecuse, DDS, a 1921 graduate of the University of Michigan School of Dentistry. The Museum officially opened on September 18, 1992 after hiring its first professional part-time curator the prior year. At its founding, the Sindecuse Museum was housed within the first and ground floor lobby areas of the Kellogg Institute Building. In 1995, plans were initiated to expand the museum as part of the Kellogg renovation.
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